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The means lowering sensitivity of nerve terminations

The knitting, enveloping and antiacid means
Mestnoanesteziruyushchy drugs
Means of this group widely apply in the form of ointments, plasters, aerosols, injection solutions and other dosage forms as the "distracting", soothing, anti-inflammatory drugs at various pathological processes. Action of these means is substantially caused by the reflex reactions connected with irritation of sensitive nerve terminations. More it belongs to the means irritating mucous membranes of airways, a mouth, digestive tract. However these means and means stimulating receptors of skin and hypodermic formations (including muscle tissues), render not only reflex, but also systemic humoral effect on an organism. It is necessary to consider that many "local" means are to a degree soaked up and can have all-resorptive effect and also influence various regulatory processes, including neuromediator, immune responses and so forth. It is proved that the irritation of receptors of mucous membranes, skin and hypodermic formations is followed by stimulation of education and release of the enkephalins, endorphins, dinorfinums and peptides playing an important role in regulation of pain, permeability of vessels and other processes. Under the influence of the "irritating" substances some other the endogenous physiologically active connections (a histamine, kinina, etc.) stimulating immunological processes, affecting blood clotting, etc. is released.
A number of vegetable means and also synthetic connections belongs to drugs of the "irritating" action. Due to the specific features of action and a scope in separate subgroup the funds having laxative effect are allocated.
Diseases

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