A number of the medicines improving microcirculation, normalizing permeability of the vessels reducing puffiness of fabrics of vessels and improving metabolic processes in walls of vessels in recent years found broad application at treatment of various angiopatiya: diabetic angiopatiya (including retinopathies, nefropatiya, defeats of cerebral and coronary vessels, vessels of the lower extremities, etc.), disturbances of permeability of vessels in rheumatoid diseases, atherosclerotic defeats of vessels, diseases of veins with the stagnant and inflammatory phenomena and also in trophic ulcers, the disturbances of permeability connected with overdose of anticoagulants, etc.
Angioprotektornoye (or kapillyaroprotektorny) drugs of group of vitamin P (cm), ascorbic acid, anti-inflammatory substances, especially nonsteroid, etc. have effect.
Now as very effective vasoprotectives Parmidinum, etamsylate, calcium dobezilat, K Tribenozidum and also drugs of plant origin - K Escuzanum, esflazid, semi-synthetic production of Rutinum - K Troxevasinum, etc. began to use drugs K.
The mechanism of action of vasoprotectives is various. A part is played the inhibiting influence on activity of hyaluronidase (see Lidaz), by slowing down of biosynthesis of prostaglandins, antibradikininovy action and other factors.
Often vasoprotectives include in complex pathogenetic therapy.