In recent years it was revealed that some derivatives of desoxycholeic acid, in particular ursodezoksikholevy acid (UDHK), are capable to dissolve the cholesteric stones which are formed in a gall bladder. Isomerous henodezoksikholovy acid (HDHK) has the same effect. It is established that these acids lower cholesterol content in bile, increase the level of bile acids a little. Studying effect of these acids laid the foundation for their use in medicine as cholelitholytic means. Both drugs are used only at formation of cholesteric stones (at their small size); they are effective in small percent of cases.
Nevertheless these drugs opened new opportunities of treatment of cholelithiasis and are addition to the main (surgical) or udarnovolnovy way of removal of gallstones.
Now researches on search of new litolitichesky drugs are actively conducted.
The main drug produced abroad is chenodesoxycholic acid (henodiol, henofalk). Also drug of ursodezoksikholevy acid urzofalk is produced.