Hormones - biologically active agents produced by closed glands or separate cells in various fabrics (histihormones), humoral intermediaries of central nervous system in influence on fabrics and bodies. The role of hormones at the insufficient or increased function of glands is especially brightly shown. Often apply hormonal means (the replacement, stimulating therapy) to treatment of endocrine diseases.
Gormonopreparata receive from tissues of animals (vidonespetsifichesky), the person (species-specific), a synthetic and semi-synthetic way (in these cases the receiving drug with the set properties is possible) and also a so-called recombinant way (so receive the drugs identical on structure to human hormones).
Anti-hormonal means — the medicines weakening or terminating hormones (for example, Mercazolil).
Anti-hormones (antihormona) — the natural and synthetic substances capable to suppress biosynthesis, secretion, transport or effect of hormones.
Hormonal drugs classify by the chemical building on belkovopeptidny (gormonopreparata of a hypothalamus, a hypophysis, epithelial bodies, thyrocalcitonin, drugs of hormones of pancreatic and thymic glands and also histihormones), steroid (glucocorticoids, mineralokortikoida, androgens, estrogen, gestagena, steroid anabolic steroids) and hormones of the amino-acid building (noradrenaline, adrenaline, thyroxine, triiodothyronine). Synthetic substitutes of hormones differ in pharmacokinetic characteristics (and in some cases - and pharmakodinamichesky properties).
Some hormonal drugs found application at treatment of not endocrine diseases (nonspecific hormonal therapy). In this case they are entered without an endocrine background of the patient and in high doses - counting on specific effect of drug. All other effects are undesirable and at prolonged use can constitute danger. For reduction of risk of complications use different methods, schemes of treatment and a dosage of drugs. More widely than other hormonal drugs for nonspecific hormonal therapy use drugs of glucocorticoids.
Anti-hormonal means or interfere with synthesis, removal and activation of hormones, or break gipotalamo-hypophysial regulation of function of gland, or block hormone receptors. They are applied at hyperfunction of gland and to palliative treatment of hormonedependent tumors of closed glands and hormonedependent fabrics. Of a number of anti-hormones it is characteristic agonist - antagonistic activity therefore their effects qualitatively depend on a background of endogenous hormones and a dose of the used drugs.