MEKSIDOL (Mexidolum). 3-oxy-6-methyl-2-ethylpyridine succinate.
Crystal powder, white or white with creamy shade. Let's easily dissolve in water.
On chemical structure meksidol is the salt of succinic acid corresponding to an emoksipin (succinate).
Like an emoksipin, meksidol is inhibitor of freely radical processes (antioxidant), but has more significant anti-hypoxemic effect.
Meksidol possesses a wide range of biological activity. It is effective at different types of a hypoxia: has more significant and long effect, than Dibunolum (ionol). Drug increases resistance of an organism to kislorodzavisimy morbid conditions (shock, disturbances of cerebral circulation, etc.), improves mnestic functions, reduces toxic effects of alcohol, etc.
Meksidol is offered for treatment of acute disorders of cerebral circulation, distsirkulyatorny encephalopathy, vegeto-vascular dystonia, atherosclerotic disturbances of functions of a brain, for stopping of an abstinence syndrome in alcoholism and drug addiction, at other states which are followed by a hypoxia of fabrics.
Apply meksidol intramusculary or intravenously (struyno or by drop infusion). Struyno is recommended to administer the drug for stopping of an abstinence syndrome and vegetative and sympathoadrenal paroxysms, and by drop infusion in acute disorders of cerebral circulation.
At intravenous administration as solvent it is recommended to use sterile water for injections. Struyno meksidol is entered within 5 - 7 min., by drop infusion, with a speed of 60 thaws a minute. Doses are appointed individually.
Begin treatment with a dose of 100 mg of 1 - 3 time a day, gradually raising a dose to obtaining therapeutic effect. Duration of treatment and the choice of an individual dose depend on weight of a condition of the patient and efficiency of treatment. The maximum daily dose should not exceed 800 mg.
For treatment of an acute disorder of cerebral circulation (stroke), meksidol 3 times a day appoint intravenously by drop infusion in a dose 200 - 300 mg in the first 2 - 4 days, and then intramusculary on 100 mg.
The patient with distsirkulyatorny encephalopathy and vegeto-vascular dystonia the drug is administered intramusculary in a dose of 50 - 100 mg by 3 times a day.
In an abstinence syndrome meksidol enter about a dose 100 - 200 mg intramusculary 2 - 3 times a day or intravenously (by drop infusion) 1 - 2 time a day, and in neurotic and neurosis-like disorders appoint intramusculary in a dose 50 - 400 mg a day.
At patients of advanced age meksidol apply to treatment of atherosclerotic weak-mindedness intramusculary in a dose 100 - 300 mg a day.
In acute antipsychotic intoxication drug is used intravenously struyno in a dose of 50 - 300 mg a day.
Usually meksidol it is well transferred. At some patients the appearance of nausea and dryness in a mouth is possible.
Drug is contraindicated at the significant disturbances of functions of a liver and kidneys, in the presence in the anamnesis of an allergy to a pyridoxine (vitamin B 6) [on chemical structure meksidol has similarity to a pyridoxine (see)].
Packaging: 5% solution in ampoules on 2 ml.
Storage: B list. In the place protected from light.