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Prazikvantel

instruction for use



PRAZIKVANTEL (Praziquantel). 2 (Tsiklohexilkarbonil)-1, 2, 3, 6, 7, 11b-hexahydro-4H-пиразино [2, 1] - isoquinoline - 4 - it.

Synonyms: Biltride, Cesol, Cestox, Cistricid, Droncit, Pyquiton.

Domestic name 'Azinoks' (Azinox).

The white crystal powder bitter on taste.

Is highly effective means for treatment of shistosomatoz and trematodoses.

It is quickly soaked up at intake. The peak of concentration in blood plasma is observed in 1 - 2 h. About 80% in the form of metabolites by kidneys during 4 days are quickly metabolized and removed, at the same time 90% are removed in the first 24 h.

In the mechanism of action of a prazikvantel the increase under its influence of permeability of cellular membranes of parasites is important for calcium ions. Drug causes the reduction of muscles of parasites passing into spastic paralysis.

Appoint a prazikvantel inside within 1 - 2 days. Accept in day usually 25 mg/kg 3 times or 30 - 40 mg/kg 2 times.

Drug gives high medical effect (to 100%) and is usually well transferred. Nausea, a headache, pains in epigastric area are in some cases observed. These phenomena pass usually after the end of administration of drug.

In comparison with hloksily the prazikvantel is more effective and is better had.

Packaging: tablets.

3. ANTIMONIL-NATRIYA TARTRATE (Stibii et Natrii tartras).

Synonyms: Vinnosurmyannonatriyevy salt, Sodium vinnosurmyanokisly, Natrium tartaricostibium, Sodium Antimony tartrate, Stibii et Natrii tartras, Stibnal, Stibyal, Tartarus Stibiatus natronatus.

White crystal powder. Let's dissolve in water.

It is used for treatment of shistosomatoz. Due to the complexity of use and by-effects of broad use has no.

Enter intravenously in the form of 1% of solution on isotonic solution of sodium of chloride with addition 5% of glucose. Solution has to be freshly cooked, sterilized in the autoclave or on the water bath. Enter slowly (no more than 2 ml a minute). Treatment is carried out only in a hospital.

Various schemes are offered. 1. The drug is administered daily, by only 20 injections. Single dose (it daily) 1, 0 - 1, 2 mg/kg. The general dose on a course of treatment should not exceed 1, 3 g of drug (130 ml of 1% of solution). In order to avoid by-effects a dose, after 10 - 11 injections reduce a little, and from the 15th injection raise again. So for example, to the patient with the body weight of 60 kg enter the first time of 5 ml of 1% of solution, from 2nd to the 11th injection - 7 ml of the same solution, from 12th on the 15th injection on 5 ml, and from 16th on the 20th injection - on 7 ml (only 130 ml). 2. Intensive course: treatment is carried out within 1 - 2 days. Do 3 injections a day with an interval of 3 h. A single dose for adults 0, 06 - 0, 12 (6 - 12 ml of 1% of solution).

There are also other schemes of treatment.

It is necessary to consider that at use of drug various by-effects are possible: nausea, vomiting, headache, arthralgias, skin rash, fervescence, etc. For reduction of by-effects appoint antihistaminic drugs, Unithiolum. If necessary further administration of drug is stopped.

In the place of intravenous administration the phlebitis can develop; hit of solution under skin causes sharp morbidity and hypostasis of fabrics.

Contraindications: organic heart diseases, diseases of kidneys and a liver (not connected with helminthoses), pregnancy, exhaustion, old age, periods.

Packaging: powder.

Storage: list B.


It is applied at treatment:
Hypostases (peripheral)

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