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instruction for use

SIBAZONUM (Sibazonum). 7-Chlor-2, 3-dihydro-1-methyl-5-phenyl-1H-1, 4 - benzodiazepine - 2 - it.

Synonyms: Apaurinum, Bensedin, Diazepam, Relanium, Seduxenum, Ansiolin, Apaurin, Apozepam, Atilen, Bensedin, Diapam, Diazepam, Eridan, Lembrol, Pacitrian, Quetinil, Relanium, Saromet, Seduxen, Serenamin, Serensin, Sonacon, Stesolin, Ushamir, Valitran, Valium, Vatran, Vival, etc.

Fine-crystalline powder, white or white with weak yellowish shade. It is almost insoluble in water, is difficult alcohol-soluble.

Sibazonum (diazepam) is one of the main benzodiazepine tranquilizers which found broad application in medical practice.

Drug works soothingly, removes emotional pressure, reduces feeling of alarm, fear, concern. Renders miorelaksantny and anticonvulsant effect. Strengthens effect of somnolent, narcotic, antipsychotic, analgetichesky drugs, alcohol.

Drug and its main metabolites are removed mainly with urine.

Sibazonum is appointed in various psychological diseases: neurosises, psikhopatiya and also at neurosis-like and psychopathy-like states in schizophrenia, organic lesions of a brain, including in cerebrovascular diseases, in the somatic diseases which are followed by signs of emotional pressure, alarm, fear, acrimony, senestoipokhondrichesky, persuasive and phobic disorders in sleep disorders. It is applied also to stopping of psychomotor excitement and disturbing agitation at the specified diseases.

In children's psychoneurological practice Sibazonum is appointed at the neurotic and neurosis-like states which are followed by the listed above phenomena and also headaches, enuresis, disorders of mood and behavior.

Sibazonum is applied in epilepsy to treatment of convulsive paroxysms, mental equivalents, to stopping of the epileptic status. Due to the myorelaxation action, drug is used also at different spastic states.

In a complex with other drugs appoint Sibazonum for treatment of an abstinence syndrome in alcoholism.

In anesthesiology practice it is used for preoperative training of patients.

In dermatological practice it is applied at a pruritic dermatosis.

Drug reduces night secretion of gastric juice that can play an important role when assigning it as the calming and sleeping medicine the patient with a peptic ulcer of a stomach; has also antiarrhytmic effect.

Apply Sibazonum inside, intravenously or intramusculary.

At intake it is recommended to appoint drug adult, since a dose 0, 0025 - 0, 005 g (2, 5 - 5 mg) of 1 - 2 time a day, and then gradually to increase it. Usually single dose for adults makes 0, 005 - 0, 01 g (5 - 10 mg). In some cases (at overexcitement, fear, alarm) it is possible to increase a single dose to 0, 02 g (20 mg). At treatment in a hospital and at thorough medical observation the daily dose can reach 0, 045 g (45 mg). At out-patient treatment it is not recommended to appoint more than 0, 025 g (25 mg) a day.

Maximum daily dose 0, 06 g (6O of mg). The daily medical dose is given in 2 - 3 receptions.

The weakened and elderly people are recommended to take the drug in the reduced doses (0, 0025 g = 1/2 g of tablet 1 - 2 times a day).

In sleep disorders the adult appoint 1 - 2 tablet before going to bed.

To children Sibazonum is appointed inside in the following single doses: aged from 1 year up to 3 years - 0, 001 g (1 mg), from 3 to 7 years - 0, 002 g (2 mg), of 7 years are also more senior - 0, 003 - 0, 005 g (3 - 5 mg). Daily doses make respectively 0, 002 g (2 mg), 0, 006 g (6 mg) and 0, 008 - 0, 01 g (8 - 10 mg).

Children of advanced age can increase if necessary a daily dose to 0, 014-0, 016 g (14 - 16 mg).

Cancellation of Sibazonum should be carried out by a gradual dose decline. Owing to possible development of psychological dependence duration of a continuous course of treatment should not exceed 2 months. Before a repeated course of treatment a break not less than 3 weeks.

Intravenously (by drop infusion or struyno) and intramusculary the drug is administered the adult mainly in the diseases which are followed by psychomotor excitement, spasms during the stopping of the epileptic status, treatment sharp alarming and phobic, alarming depressions, including in alcoholic psychoses and abstinency. The average single dose makes 10 mg (2 ml 0, 5% of solution), average daily - 30 mg. Maximum dose: single 30 mg, daily 70 mg.

Sedation is observed already in a few minutes after intravenous and in 30 - 40 min. after intramuscular administration of Sibazonum, therapeutic action - in 3 - 10 days. After removal of acute manifestations of a disease Sibazonum is appointed inside.

At the epileptic status Sibazonum is entered intravenously slowly in a dose from 10 to 40 mg. It is possible if it is necessary, to repeat intravenous or intramuscular administration each 3 - 4 h (3 - 4 times). The highest effect is observed at early prescribing of Sibazonum in the first 3 h after approach of the status in the form of generalized attacks.

Sibazonum (diazepam) is used for premedication and an ataralgeziya in combination with analgetika and other neurotropic drugs.

Possible complications, contraindications and precautionary measures generally same, as for Chlozepidum. At intravenous administration of solution of Sibazonum, local inflammatory processes in this connection it is recommended to change the injection site of drug can be observed.

Solution of Sibazonum should not be entered in one syringe with other drugs in order to avoid loss of a deposit.

Packagings: tablets on 0, 005 g (5 mg) of color, white or white with a weak yellowish shade, in packing on 20 pieces and also tablets for children on 0, 001 and 0, 002 g (Tabulettae Sibazoni obductae 0, 001 aut 0, 002 pro infantibus) of orange or yellow color in packing on 20 pieces in banks of orange glass: 0, 5% solution in ampoules (Solutio Sibazoni 0, 5% of pro injectionibus) on 2 ml in packing on 10 ampoules.

Storage: B list. In the place protected from light (ampoules store at a temperature not higher than + 5 C).

Some foreign firms produce diazepam (under different names) not only in the form of tablets and solutions for injections, but also in the form of suppositories (on 5 mg of drug) and solutions for intake (on 2 mg in 1 ml in bottles on 100 ml).

Diazepam is a component of somnolent drug Reladormum (see Tsiklobarbital).

It is applied at treatment:
Algodismenorey, Athetosis, Insomnia, hypertension, Neurangiosis, Hysteria, Climax female, Menopausal syndrome, Contractures, Myalgia, Migraine, Drug addiction, Neuralgia, Epileptiform neuralgia, Neurasthenia, Manic-depressive psychosis, Vomiting, Nausea, Paralyses (spastic), Spasms, Schizophrenia, Eczema, Epilepsy, Peptic ulcer of a stomach and duodenum, Arterial hypertension, Hypertension, Psychosis, Spasms of skeletal muscles

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