Bile-expelling means can be divided into 2 groups: the means strengthening formation of bile and bile acids (Choleretica or Cholesecretica), and the means promoting biliation from a gall bladder in intestines (Cholagoga, or Cholekinetica).
The drugs containing bile acids and bile belong to the I subgroup: Allocholum, liobit, Cholenzymum, etc., a number of means of plant origin (immortelle flowers, corn stigmas, Flacuminum, Convaflavinum, berberine, etc.) and also some synthetic drugs (oksafenamid, Nicodinum, Cycvalonum).
The mechanism of effect of holeretichesky substances is caused by reflexes from a mucous membrane of intestines (especially at the use of drugs of bile and bile acids and drugs containing essential oils) and also their influence on secretory function of a parenchyma of a liver. They increase amount of the cosecreted bile, raise an osmotic gradient between bile and blood that strengthens osmotic filtration in bilious capillaries of water and electrolytes, increase bile current on bilious ways and the maintenance of dressing gowns in bile, reduce a possibility of settling out of cholesterol of bile that prevents formation of gallstones. They strengthen also secretory and motive functions of digestive tract.
The drugs containing bile and bile acids can serve as means of replacement therapy at endogenous insufficiency of bile acids.
The drugs promoting biliation can work, raising a tone of a gall bladder (holekinetika) and/or lowering a tone of bilious ways and Oddi's (holespazmolitik) sphincter.
Sulfate, barberry and some other drugs have Holekinetichesky effect magnesium. Relaxation of a tone of bilious ways various antispasmodics (a papaverine, Nospanum, Olimetinum, etc.) cause, cholinolytics and also nitrates, Euphyllinum, etc.
The majority of bile-expelling drugs has the combined effect, strengthening biliary secretion and facilitating its receipt in intestines, and some drugs at the same time render anti-inflammatory (Cycvalonum) and antibacterial (Nicodinum) action.
It is necessary to consider that action of bile-expelling means to some extent has "hepatoprotective" character. Facilitating outflow of bile and reducing these load of a liver parenchyma, facilitating a blood stream, reducing the inflammatory phenomena, bile-expelling means promote improvement of the general functional condition of a liver.
The bile-expelling herbs and collecting increasing production of bile: Sandy immortelle, Grass immortelle, Barberry ordinary, Barberry Amur, Corn, Thistle spotty, Pizhma ordinary, Lily of the valley Keisk, Goldenrod, Datisca