PHENAZEPAMUM (Phenazepamum). 7-Brom-5-(ortho-chlorophenyl)-2, 3-dihydro-1H-1, 4 - benzodiazepine - 2 - it.
Crystal powder, white or white with creamy shade. It is insoluble in water, is a little alcohol-soluble.
Phenazepamum is domestic highly active tranquilizer. On force of tranquilizing and anxiolytic action exceeds other tranquilizers; renders also significant anticonvulsant, miorelaksantny and somnolent action. At use together with hypnotic drugs and drugs there is mutual strengthening of influence on central nervous system.
Phenazepamum is appointed at various neurotic, neurosis-like, psychopathic and psychopathy-like states which are followed by alarm, fear, acrimony, emotional lability. Drug is effective at persistence, a phobia, hypochondriac syndromes (including other tranquilizers, resistant to action), is shown also in psychogenic psychoses, panic reactions, etc. as removes a condition of alarm and fear. Phenazepamum on force sedative and mainly does not concede antidisturbing action to some neuroleptics.
Phenazepamum is applied also to stopping of alcoholic abstinency. Besides, appoint as anticonvulsant and sleeping medicine. On force of somnolent action approaches nitrazepam.
It can also be applied to premedication by preparation for surgeries.
Appoint Phenazepamum inside in the form of tablets. In out-patient conditions appoint the adult 0, 00025 - 0, 0005 g (0, 25 - 0, 5 mg) 2 - 3 times a day. In the conditions of a hospital the daily dose can be increased up to 0, 003 - 0, 005 g (3 - 5 mg); at treatment of epilepsy the daily dose makes from 0, 002 to 0, 01 g (2 - 10 mg).
For stopping of alcoholic abstinency appoint 0, 0025 - 0, 005 g (2, 5 - 5 mg) a day. In sleep disorders accept on 0, 00025 - 0, 001 g (0, 25 - 1 mg) in 20 - 30 min. prior to a dream. Sometimes the dose is increased to 0, 0025 g (2, 5 mg). The maximum daily dose should not exceed 0, 01 g.
Possible by-effects and contraindications same, as for Chlozepidum and Sibazonum. It is necessary to consider that in connection with high activity of Phenazepamum the ataxy, drowsiness, muscle weakness, dizziness [as the proofreader reducing or reducing side effect of Phenazepamum can be observed more often (and other derivatives of benzodiazepine) Sydnocarbum (see Sydnocarbum)] can be used.
Packaging: tablets of white color on 0, 0005 and 0, 001 g (0, 5 and 1 mg) in packing on 50 pieces and on 0, 0025 g (2, 5 mg) in packing on 20 pieces.
Storage: B list. In the dry, cool, protected from light place.