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instruction for use

Trade name of drug: REFNOT (Refnot)

Active agent: Factor of necrosis of tumors Timosinums alfa-1 recombinant (Tumor necrosis factor-thymosine alpha-1 recombinant)


Drug represents the friable or porous mass of white color, is hygroscopic.

Pharmacotherapeutic group: antineoplastic.


The drug REFNOT® possesses direct antineoplastic action of in vitro and in vivo on various lines of tumor cells. On a range of cytotoxic and cytostatic action on tumor cells drug corresponds to tumor necrosis factor α (FNO) of the person, however the drug REFNOT® has more than by 100 times smaller general toxicity, than FNO.

The mechanism of antineoplastic effect of the drug REFNOT® in vivo includes several ways which drug destroys a tumor or stops its growth:

- immediate effect of a factor of necrosis of tumors Timosinums alfa-1 (FNO-T) on tumoral target cell through the corresponding receptors on its surface therefore there is cell apoptosis (cytotoxic action) or a stop of a cellular cycle (cytostatic action);

- the cascade of chemical changes including activation of a coagulative system of blood and the local inflammatory reactions caused РЕФНОТ®-активированными by cells of an endothelium and lymphocytes and leading to hemorrhagic necrosis of tumors;

- the angiogenesis blocking leading to germination reduction by new vessels of a fast-growing tumor and, as a result, to decrease in blood supply up to necrosis of the center of a tumor;

- influence of cells of the immune system which cytotoxicity was closely connected with existence of molecules FNO-T on their surface or process of maturing/activation of these cells it is connected with the answer to FNO-T.

Combinations РЕФНОТ® with α2- or γ-interferonam have synergy cytotoxic effect. РЕФНОТ® scale by 100–1000 times enhances protivirusny activity of recombinant interferon (against a virus of vesicular stomatitis).

РЕФНОТ® increases efficiency of khimiopreparat: Actinomycinum D, Cytarabinum, doxorubicine against tumor cells poorly sensitive to them, liquidating this resistance. It allows to consider РЕФНОТ® as the modifier of antineoplastic action of chemical tsitostatik in cases of multiple drug resistance of tumor cells.

РЕФНОТ® has no cytotoxic effect on normal cells and stimulates proliferation of cells of a spleen and lymph nodes in high concentrations of in vitro. Strengthens products of antibodies on T-dependent antigens, has the stimulating impact on cytotoxic effect of natural killer cells of protivopukholevy cells, has the stimulating impact on phagocytosis, strengthens an expression of GKGS I antigens of class H-2K, CD-4 and CD-8, being a factor of differentiation T-helperov and T-killers.

Indications of the drug REFNOT®:

Breast cancer in complex therapy from khimiopreparata.

Drug REFNOT® contraindications:

hypersensitivity to FNO-T or any other component of drug;

pregnancy and period of feeding by a breast.

Route of administration and doses:

For cancer therapy of a mammary gland in a combination with chemotherapy the average daily dose of drug makes 200000 PIECES. Administer the drug p / to in day of chemotherapy (in 30 min.) and within 4 days after chemotherapy of 1 times a day.

Just before use the contents of a bottle are dissolved in 1 ml of water for injections.

Side effect of the drug REFNOT®:

The individual hypersensitivity to drug is noted. РЕФНОТ® causes in some patients short-term (till several o'clock) temperature increase on 1–2 °C, a fever.

Side effects are removed additional intake of indometacin or an ibuprofen which do not influence cytotoxic effect of drug.

Storage conditions: In the dry, protected from light place, at a temperature of 2-10 °C. Not to freeze. The dissolved drug is not subject to storage.

To store out of children's reach.

Expiration date: 2 years.

It is applied at treatment:
01.07.2015 21:35
Good afternoon! I will sell antineoplastic medicine REFNOT of 6 packs on 5 ampoules, bought to the father, were not useful. Bought in the Pharmacy "White Lotus" specified on the website (refnot.ru/buy.html), all checks are. Were transported in a thermal container, storage conditions are met. An expiration date up to 11.2016 g. I will sell for 9500 rub for 1 packing, ph. 89874221702 (in Kazan)
25.03.2016 21:34
I will sell Refnot and Ingaron, 2016, all new, all in a great view and storage. Were not necessary..... write on buran2408@yandex.ru
28.04.2016 09:36
Hello! I will sell antineoplastic medicine REFNOT. 4 packs on 5 ampoules. The price for packing 8500. Storage conditions are not violated! You call at any time: 89106038717.
08.06.2016 21:14
I will sell Refnot, remained after treatment. Bought in pharmacy from Onkoimmunologiya's Institute, there is a sales receipt. It is stored in the fridge, it is suitable till November, 2017. For packing from 5 pieces-5000 of rub in Kazan
29.06.2016 09:15
Novosibirsk, I Will sell Refnot in packing on 5 ampoules, storage conditions are met, just drug was not necessary more. 1 packing 5000 r, available 4 packs. To call by number 89139573574

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